Glucosamine and chondroitin are natural constituents found in joint tissues. Their effect on promoting and supporting joint health is most likely due to their anti-inflammatory activity in the joint and their role in the synthesis and reparation of joint cartilage.1-4 Some controversies exist over the efficacy of the glucosamine-chondroitin combination which might dissuade some supplement manufacturers from using this dual combination in their joint well being supplements. However, both glucosamine and chondroitin have been well-researched and consequently, the most popular ingredients to include in joint wellness supplements. There is enough indication from positive studies to suggest the efficacy of these two natural ingredients and therefore, their positive aspects ought to not be underestimated. Moreover, glucosamine and chondroitin are regarded as normally safe to take and not identified to have any side effects when taken in recommended dosages.
The very first study employing the combination of glucosamine and chondroitin as a dietary supplement for promoting joint wellness was published in 1969. The outcomes of this initial study suggested that both ingredients could relieve joint pain and consequently led to more extensive investigations. Regrettably, several of the studies that followed had been flawed—they had been too short, modest or employed differing dosages producing comparison and interpretation challenging. For example, a systematic review of glucosamine and chondroitin in 2000 suggested that this combination may possibly not only help to relieve joint pain but may also boost joint mobility. Due to the poor-high quality of these trials nonetheless, interpretation of the information was hard and results had been ultimately compromised.five
In 2006, the outcomes of the country’s initial six-month big-scale study on the use of glucosamine and chondroitin known as the Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT) had been eagerly awaited both by the medical profession and buyers. In the study 1,583 people who suffered from knee osteoarthritis had been divided into five groups and each group was assigned to one of five treatments—a placebo, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), chondroitin alone, glucosamine alone, or a combination of glucosamine and chondroitin. The results? Twenty-two percent (354) of the participants who suffered from mild to severe joint discomfort experienced a 20 percent reduction in joint discomfort as compared to the placebo group.6
In 2007, a review by Bruyere concluded that the administration of glucosamine and chondroitin might be beneficial as important symptomatic therapy for osteoarthritis, showing possible for structural-modifying effects. The study suggests that a glucosamine-chondroitin joint support formula may possibly assist lessen joint discomfort, boost joint function and mobility as well as help stop or delay the onset of osteoarthritis. 7
Following performing a systematic review of treatment guidelines for osteoarthritis, the OsteoArthritis Investigation Society International (OARSI) consisting of 16 specialists from 6 countries, released 25 evidence-based professional-consensus recommendations for osteoarthritis in February 2008. They recommended glucosamine and /or chondroitin for symptom relief of joint discomfort by a 63 percent majority.8
Joint discomfort has already affected 46 million of Americans, according to statistics from the Centers for Disease Control and Prevention, 9 and given that degeneration of joint health is associated with increasing age11, consumer demand for joint well being supplements is rapidly growing.
By 2011, 78 million baby boomers will turn 65, and every year for the 18 years that follow between 3 and 4 million Americans will turn 65.10
Vitacap Labs’ private label joint support formula contains the nicely-researched ingredients glucosamine sulfate and chondroitin sulfate along with other science-supported ingredients that aid promote joint wellness such as MSM, Vitamin D3 and calcium citrate. Their GMP-certified facility assures you, and specially your buyers, of a high-high quality, premium joint support supplement. In addition, manufacturing with Vitacap Labs gives you the convenient advantage of selecting from an assortment of premium private label formulas to meet the minimum order quantity of just 96 bottles. For more information, or to place an order, contact 1 of their knowledgeable service specialists today, or Click Here to request a totally free quote.
Ronca F, Palmieri L, Panicucci P, Ronca G. Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis Cartilage. 19986 Suppl A:14-21.
Monfort J, Pelletier J-P, Garcia-Giralt N, Martel-Pelletier J. Biochemical basis of the effect of chondroitin sulfate on osteoarthritis articular tissues. Ann Rheum Dis 2007 doi:10.1136/ard.2006.068882.
Muller-Fabbender H, Bach GL, Haase W, Rovati LC, Setnikar I. Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis Cartilage. 19942:61–69.
Glucosamine sulfate. Altern Med Rev. 19994:193–195.
McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA. 2000283:1469–75.
Questions and Answers: NIH Glucosamine/chondroitin Arthritis Intervention Trial Primary Study. http://nccam.nih.gov/research/outcomes/gait/qa.htm
Bruyere O., Reginster J.Y. Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis. Drugs Aging, 2007 24 (7): 573-580
Osteoarthritis: Which Treatments Function and Which Do not? Osteoarthritis Analysis Society International (OARSI). February 15, 2008. http://www.oarsi.org/pdfs/pr_080215_guidelines.pdf
http://www.cdc.gov/arthritis/data_statistics.htm
Aging Baby Boomers: http://www.wikinvest.com/idea/Aging_Baby_Boomers
National Institute of Aging: http://www.nia.nih.gov/HealthInformation/Publications/arthritis.htm
Related posts: